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| | Rushing | Tm | Att. | Yds. | Avg. | LG | TD | | |
| 1. | Railey, Carlos | Fred | 9 | 106 | 11.8 | 0 | 1 | | 07/10/10 vs New Jersey Broncos |
| 2. | Johnson, Richard | Wil | 11 | 95 | 8.6 | 0 | 0 | | 08/28/10 vs Virginia Ravens |
| 3. | Corbett, Michael, Jr. | Arb | 9 | 79 | 8.8 | 0 | 1 | | 08/07/10 at Valley Tigers |
| 4. | Johnson, Richard | Wil | 9 | 72 | 8.0 | 17 | 1 | | 07/31/10 vs Jacksonville Raiders |
| 5. | Green, Nick | Wil | 7 | 71 | 10.1 | 22 | 0 | | 07/24/10 at Virginia Ravens |
| 6. | Collins, Kelvin | Arb | 14 | 70 | 5.0 | 0 | 0 | | 08/21/10 vs New Jersey Broncos |
| 7. | Byrd, Willie | Wil | 7 | 67 | 9.6 | 15 | 1 | | 07/24/10 at Virginia Ravens |
| 8. | Vescogni, Jon | Fred | 8 | 64 | 8.0 | 0 | 0 | | 07/10/10 vs New Jersey Broncos |
| 9. | Williams, Demarrois | Fay | 13 | 62 | 4.8 | 0 | 1 | | 08/21/10 at Jacksonville Raiders |
| 10. | Gilbet, Lonnie | VirC | 7 | 60 | 8.6 | 0 | 0 | | 08/14/10 at Virginia Ravens |
| | Green, Nick | Wil | 6 | 60 | 10.0 | 16 | 0 | | 07/31/10 vs Jacksonville Raiders |
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